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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

cysteine proteases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HCV Protease (1) Ser/Thr Protease (2) Virus Protease (2) Apoptosis (2) Atg4 (2) Autophagy (3) Bacterial (1) Caspase (2) Cathepsin (21) CCR (1) Cytochrome P450 (1) Deubiquitinase (1) Elastase (1) Endogenous Metabolite (1) Filovirus (1) Fluorescent Dye (2) Fungal (1) HSV (2) Legumain (1) Parasite (5) PKC (1) Proteasome (3) SARS-CoV (10) Separase (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (1) Infection (18) Inflammation/Immunology (9) Metabolic Disease (2) Neurological Disease (4)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Ser/Thr Protease ASCT HCV Protease HIV Protease Virus Protease Protease Activated Receptor (PAR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0241

2-Cyanopyrimidine	Cathepsin	Metabolic Disease
2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC₅₀ of 170 nM. 2-Cyanopyrimidine is used for osteoporos .

HY-18234A

Leupeptin hemisulfate 25+ Cited Publications	Cathepsin Ser/Thr Protease Virus Protease	Infection Inflammation/Immunology
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, *cysteine* and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-W790014

Z-FG-NHO-BzOME

Cathepsin Infection

Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain .

Z-FG-NHO-BzOME	Cathepsin	Infection
Z-FG-NHO-BzOME is a **cysteine protease** inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain .

HY-18234

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, *cysteine* and threonine proteases. Leupeptin inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-P5975

Z-Leu-Leu-Leu-fluoromethyl ketone Z-LLL-FMK	Cathepsin SARS-CoV	Infection
Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a **cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS** infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge .

HY-E70226

Cathepsin S, human CTSS	Others	Cardiovascular Disease Inflammation/Immunology Cancer
Cathepsin S, human, is a potent cysteine protease that promotes the degradation of damaged or harmful proteins in the endolysosomal pathway. Cathepsin S, human, is involved in multiple pathological processes, including arthritis, cancer, and cardiovascular disease .

HY-N12129

6,6′-Dihydroxythiobinupharidine	Cathepsin	Others
6,6′-Dihydroxythiobinupharidine is a **cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ** ~8-fold and ~3-fold, respectively .

HY-119293

K777 1 Publications Verification	Cathepsin CCR Cytochrome P450 Parasite SARS-CoV Filovirus	Infection Cancer
K777 is a potent, orally active and irreversible **cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC₅₀ of 60 nM and a selective CCR4** antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC₅₀ values of 0.68 nM and 0.87 nM, respectively .

HY-143714

Cathepsin K inhibitor 2	Cathepsin	Inflammation/Immunology
Cathepsin K inhibitor 2 is a potent inhibitor of cathepsin K. Cathepsin K, Cat K is a cysteine protease expressed under the control of CTSK gene and closely related to osteoporosis, whose main function is to hydrolyze collagen. Cathepsin K inhibitor 2 has the potential for the research of osteoarthfitis (extracted from patent WO2021147882A1, compound 78) .

HY-108137

Z-LVG-CHN2 2 Publications Verification	Cathepsin HSV SARS-CoV	Infection Inflammation/Immunology
Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC₅₀=190 nM) via inhibition of SARS-COV-2 3CL pro protease .

HY-128971

LHVS	Cathepsin Parasite	Infection Neurological Disease
LHVS is a potent, non-selective, irreversible, cell-permeable **cysteine protease and cathepsin** inhibitor. LHVS decreases actin ring formation. LHVS inhibits T. gondii invasion with an IC₅₀ of 10 μM .

HY-108137A

Z-L(D-Val)G-CHN2	Cathepsin HSV SARS-CoV	Infection
Z-L(D-Val)G-CHN2 is the isoform of Z-LVG-CHN2 (HY-108137). Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC₅₀=190 nM) via inhibition of SARS-COV-2 3CL pro protease .

HY-17541

Cysteine Protease inhibitor

3 Publications Verification

Cathepsin Others

Cysteine Protease inhibitor is an inhibitor of cysteine protease.
HY-17541A

Cysteine Protease inhibitor hydrochloride

3 Publications Verification

Cathepsin Others

Cysteine Protease inhibitor hydrochloride is an inhibitor of cysteine protease.

Cysteine Protease inhibitor 3 Publications Verification	Cathepsin	Others
Cysteine Protease inhibitor is an inhibitor of **cysteine protease**.

Cysteine Protease inhibitor hydrochloride 3 Publications Verification	Cathepsin	Others
Cysteine Protease inhibitor hydrochloride is an inhibitor of **cysteine protease**.

HY-155054

Cysteine protease inhibitor-3	Parasite	Infection
Cysteine protease inhibitor-3 (Compound 15) is a **Cysteine protease** inhibitor. Cysteine protease inhibitor-3 inhibits Pf3D7, PfW2, PfFP2 and PfFP3 with IC₅₀s of 0.74 μM, 1.05 μM, 3.5 μM, and 4.9 μM, respectively. Cysteine protease inhibitor-3 has anti-plasmodial efficacy against both drug-sensitive and drug-resistant parasites .

HY-B0496

PMSF Maximum Cited Publications 64 Publications Verification Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride	Cathepsin	Others
PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates.

HY-P1006

Ac-DEVD-pNA

Caspase Others

Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases.

Ac-DEVD-pNA	Caspase	Others
Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases.

HY-P1645

Papain 5+ Cited Publications	Cathepsin	Inflammation/Immunology
Papain is a cysteine protease of the peptidase C1 family, which is used in food, pharmaceutical, textile, and cosmetic industries.

HY-15282

E-64 5+ Cited Publications Proteinase inhibitor E 64	Cathepsin Autophagy Bacterial	Inflammation/Immunology Cancer
E-64 (Proteinase inhibitor E 64) is a potent irreversible inhibitor against general **cysteine proteases with IC₅₀ of 9 nM for papain**.

HY-146649

LmCPB-IN-1

Parasite Cathepsin Infection

LmCPB-IN-1 (compound 35) is a potent and reversible covalent Leishmania mexicana cysteine protease B (LmCPB) inhibitor with a pK_i of 9.7 .

LmCPB-IN-1	Parasite Cathepsin	Infection
LmCPB-IN-1 (compound 35) is a potent and reversible covalent Leishmania mexicana cysteine protease B (LmCPB) inhibitor with a pK_i of 9.7 .

HY-100227

E 64c 2 Publications Verification
E 64c is a derivative of naturally occurring epoxide inhibitor of **cysteine proteases*, a Calcium-activated neutral protease* (CANP) inhibitor and a very weak irreversible cathepsin C inhibitor. E 64c exhibits entry-blocking effect for MERS-CoV.

HY-12412

ML132 NCGC-00183434	Caspase	Inflammation/Immunology Cancer
ML132 (NCGC-00183434) is a selective caspase 1 inhibitor with an IC₅₀ of 34.9 nM. ML132 shows good stability that can be utilized as molecular probes of caspase 1. ML132 can be used for research in the field of anti-cancer and anti-inflammatory .

HY-126973

BI-1230	HCV Protease	Infection
BI-1230 is potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. BI-1230 shows good Pharmacokinetic(PK) activity .

HY-125169

NSC 185058

Autophagy Atg4 Cancer

NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. Inhibition of ATG4B using NSC 185058 markedly attenuates autophagic activity .

NSC 185058	Autophagy Atg4	Cancer
NSC 185058 is an inhibitor of ATG4B, a major **cysteine protease**. Inhibition of ATG4B using NSC 185058 markedly attenuates autophagic activity .

HY-100229

Aloxistatin 45+ Cited Publications E64d; E64c ethyl ester	Cathepsin SARS-CoV	Neurological Disease
Aloxistatin (E64d) is a cell-permeable and irreversible broad-spectrum **cysteine protease** inhibitor. Aloxistatin (E64d) exhibits entry-blocking effect for MERS-CoV.

HY-112818

S130	Atg4 Cathepsin Autophagy Apoptosis	Cancer
S130 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC₅₀ of 3.24 µM. S130 suppresses autophagy flux .

HY-P2065

Ac-VEID-AMC	Fluorescent Dye	Others
Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .

HY-E70197

Calpain-1 (pig)

μ-Calpain
Cathepsin Others

Calpain-1 (pig) (μ-Calpain) is an intracellular Ca ²⁺-regulated cysteine protease. Calpain-1 (pig) exhibits neuroprotective effect .

Calpain-1 (pig) μ-Calpain	Cathepsin	Others
Calpain-1 (pig) (μ-Calpain) is an intracellular Ca ²⁺-regulated cysteine protease. Calpain-1 (pig) exhibits neuroprotective effect .

HY-115753

Calpain Inhibitor-1	Proteasome	Neurological Disease
Calpain Inhibitor-1 (compound 36) is a potent and selective cysteine protease calpain 1 (Cal1) inhibitor (IC₅₀=100 nM; K_i=2.89 μM) .

HY-150242A

Cbz-Ala-Ala-Asn TFA	Others	Others
Cbz-Ala-Ala-Asn TFA is a peptide that designed based on the sequence of the substrate of legumain. Legumain is a cysteine protease. Cbz-Ala-Ala-Asn TFA can be applied as a scaffold for drug delivery .

HY-E70228

Cathepsin H, human liver	Others	Cancer
Cathepsin H, human liver is an aminopeptidase and an endopeptidase. Involved in the catabolism of proteins in the lysosomal system. Cathepsin H, human liver has a key role in the regulation of the biological behavior of tumor cells and the pathological processes of brain diseases .

HY-D0843

N-Ethylmaleimide 5+ Cited Publications NEM
N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible **cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC₅₀** value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides .

HY-18236

MDL-28170 5+ Cited Publications Calpain Inhibitor III	Proteasome	Neurological Disease Inflammation/Immunology
MDL-28170 (Calpain Inhibitor III) is a potent, selective and membrane-permeable cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration . MDL-28170 also block γ-secretase .

HY-126988

SP-Chymostatin B α-MAPI	Elastase	Others
SP-Chymostatin B (α-MAPI) is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, H, and L. SP-Chymostatin B weakly inhibits human leucocyte elastase .

HY-18964

MG-101 5+ Cited Publications Calpain inhibitor I; Ac-LLnL-CHO; ALLN	Proteasome Apoptosis	Cancer
MG-101 (ALLN) is an inhibitor of **cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with K_i**s of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer .

HY-138084

SIC5-6	Separase	Cancer
SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target .

HY-149264

SARS-CoV-2 3CLpro-IN-13	SARS-CoV	Infection
SARS-CoV-2 3CLpro-IN-13 is a potent SARS-CoV-2 3CL protease inhibitor with an IC₅₀ value of 21 nM. SARS-CoV-2 3CLpro-IN-13 shows anti-coronavirus activity .

HY-D0843S

N-Ethylmaleimide-d5 NEM-d₅	Cathepsin Deubiquitinase	Others
N-Ethylmaleimide-d₅ is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor[3].

HY-138540

1-Dodecylimidazole 1 Publications Verification N-Dodecylimidazole	Fungal	Cancer
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity .

HY-P4400

Z-VDVAD-AFC	Fluorescent Dye	Others
Z-VDVAD-AFC is a fluorogenic substrate. Z-VDVAD-AFC is used to measure the activity of cysteine protease 3 (Caspase-3). Z-VDVAD-AFC undergoes hydrolysis to release 7-amino-4-trifluoromethylcoumarin (AFC). AFC is fluorescent under ultraviolet light and can emit fluorescent signals .

HY-144260

3CPLro-IN-1	SARS-CoV	Infection
3CPLro-IN-1 (compound A17) is a potent and orally active inhibitor of SARS-CoV-2 3CLpro with an IC₅₀ of 5.65 μM. 3-Chymotrypsin-like cysteine protease (3CLpro) is an indispensable protein in viral replication and represents an attractive agent target for fighting COVID-19 .

HY-144263

3CPLro-IN-2	SARS-CoV	Infection
3CPLro-IN-2 (compound C1) is a potent and orally active inhibitor of SARS-CoV-2 3CLpro with an IC₅₀ and K_i of 1.55 and 6.09 μM, respectively. 3-Chymotrypsin-like cysteine protease (3CLpro) is an indispensable protein in viral replication and represents an attractive agent target for fighting COVID-19 .

HY-E70018

Picornain 3C	Endogenous Metabolite	Infection Metabolic Disease
Picornain 3C is a protease found in picornaviruses, which cleaves peptide bonds of non-terminal sequences. Picornain 3C is an intermediate between the serine peptidase chymotrypsin and the cysteine peptidase papain. Picornain 3C shows endopeptidase activity by selectively cleaving Gln-Gly bonds in the polyprotein of poliovirus and with substitution of Glu for Gln, and Ser or Thr for Gly in other picornaviruses .

HY-144833

SARS-CoV-2 3CLpro-IN-1	SARS-CoV	Infection
SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a potent inhibitor of SARS-CoV-2 3CL ^pro. 3CL ^pro (main coronaviruses cysteine-protease) has been identified as a promising target for the development of antiviral agents. SARS-CoV-2 3CLpro-IN-1 has the potential for the research of infection diseases .

HY-137048

PF-00835231 1 Publications Verification	SARS-CoV	Infection
PF-00835231 is a CoV-2 cysteine 3C-like protease (3CL ^pro) inhibitor, with IC₅₀s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CL ^pro, respectively. PF-00835231 is developed for the research of anti-SARS-CoV-2/COVID-19 sup>[2].

HY-112205A

RR-11a analog 3 Publications Verification	Parasite Legumain	Infection
RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC₅₀ of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor .

HY-P5439

Epsilon-V1-2, Cys-conjugated	PKC	Others
Epsilon-V1-2, Cys-conjugated is a biological active peptide. (This peptide is the εPKC specific inhibitor. Its inhibitory activity is based on εPKC translocation and MARCKS phosphorylation. This peptide interferes with εPKC interaction with the anchoring protein εRACK. This peptide contains a cysteine residue added to the C-terminus for potential S-S bond formation with a carrier protein.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

Cat. No.	Product Name	Target	Research Area

HY-W790014

Z-FG-NHO-BzOME

Cathepsin Infection

Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain .
HY-P1006

Ac-DEVD-pNA

Caspase Others

Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases.

HY-18234

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, *cysteine* and threonine proteases. Leupeptin inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-P5975

Z-Leu-Leu-Leu-fluoromethyl ketone Z-LLL-FMK	Cathepsin SARS-CoV	Infection
Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a **cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS** infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge .

HY-P2780

Cathepsin B	Peptides	Others
Cathepsin B is a **cysteine protease** and is involved in multiple kinds of programmed cell death (including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death) .

HY-P2065

Ac-VEID-AMC

Fluorescent Dye Others

Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .

HY-P4400

Z-VDVAD-AFC	Fluorescent Dye	Others
Z-VDVAD-AFC is a fluorogenic substrate. Z-VDVAD-AFC is used to measure the activity of cysteine protease 3 (Caspase-3). Z-VDVAD-AFC undergoes hydrolysis to release 7-amino-4-trifluoromethylcoumarin (AFC). AFC is fluorescent under ultraviolet light and can emit fluorescent signals .

HY-P4404

Abz-GIVRAK(Dnp)	Peptides	Others
Abz-GIVRAK(Dnp) is the most efficient substrate for cathepsin B and is highly selective for this enzyme among lysosomal cysteine proteases. After Abz-GIVRAK(Dnp) is hydrolyzed, aminoacylbenziminosulfosuccinic acid (Abz-SAS) is released, and dinitrobenzoyl (Dnp) is also released. The product of this hydrolysis reaction, Abz-SAS, is fluorescent under ultraviolet light and can emit a fluorescent signal .

HY-P5378

Ac-KQKLR-AMC Cathepsin S substrate	Peptides	Others
Ac-KQKLR-AMC (Cathepsin S substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin S is a cysteine proteinase involved in the pathogenesis of autoimmune diseases, atherosclerosis, cancer, obesity and related diseases.This peptide is a cathepsin S substrate fluorescently labeled with AMC (Ex/Em=354 nm/442 nm). It can be used to measure cathepsin S activity.)

HY-P5377

Abz-HPGGPQ-EDDnp Cathepsin K substrate	Peptides	Others
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)

HY-P5439

Epsilon-V1-2, Cys-conjugated	PKC	Others
Epsilon-V1-2, Cys-conjugated is a biological active peptide. (This peptide is the εPKC specific inhibitor. Its inhibitory activity is based on εPKC translocation and MARCKS phosphorylation. This peptide interferes with εPKC interaction with the anchoring protein εRACK. This peptide contains a cysteine residue added to the C-terminus for potential S-S bond formation with a carrier protein.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18234A

Leupeptin hemisulfate 25+ Cited Publications	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Cathepsin Ser/Thr Protease Virus Protease
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, *cysteine* and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-P1645

Papain 5+ Cited Publications	Carica papaya L. Structural Classification Natural Products Classification of Application Fields Source classification Caricaceae Plants Inflammation/Immunology Disease Research Fields	Cathepsin
Papain is a cysteine protease of the peptidase C1 family, which is used in food, pharmaceutical, textile, and cosmetic industries.

HY-N12129

6,6′-Dihydroxythiobinupharidine	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Plants Nuphar pumila (Timm) de Candolle Nymphaeaceae	Cathepsin
6,6′-Dihydroxythiobinupharidine is a **cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ** ~8-fold and ~3-fold, respectively .

Cat. No.	Product Name	Chemical Structure

HY-D0843S

N-Ethylmaleimide-d5
N-Ethylmaleimide-d₅ is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor[3].

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cysteine proteases

Inhibitors & Agonists

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Biochemical Assay Reagents

Peptides

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